North Carolina Research Center

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Published Research/News

• Yang XH and Sladek TL: Overexpression of E2F-1 transcription factor gene mediates cell transformation. Gene Expr 1995; 4:195-204.
• Yang, XH and Sladek TL: Novel phosphorylated forms of E2F-1 transcription factor bind to the retinoblostoma protein in cells overexpression an E2F-1 cDNA. Biochem Biophys Res Commun 1997; 232:336-9.
• Talanian R, Yang XH, Turbov J, Seth P, Ghayur T, Casiano C, Orth K, Froelich CJ: Granule-mediated killing: Pathways for granzyme B initiated apoptosis. J Exp Med 1997; 186:1323-31
• Froelich CJ, Dixit DM, Yang XH: Lymphocyte granule-mediated apoptosis: matters of viral mimicry and deadly proteases. Immunol Today 1998; 19(1):30-5.
• Stennicke HR, Jurngensmeier J, Shin H, Wolf B, Yang XH, Zhou Q, Ellerby HM, Ellerby LM, Bredesen, Green DR, Reed JC, Froelich CJ, Salvesen GS: Pro-caspase-3 is a major physiologic target of caspase 8. J Biol Chem 1998; 273:27084-90.
• Yang XH, Stennicke H, Wang BK, Green DR, Janicke RU, Srinivasan A, Seth P, Salvesen GS, Froelich CJ: Granzyme B mimics apical caspases, description of a pathway for trans-activation of executioner caspase-3 and 7. J Biol Chem 1998; 273(51):34278-83.
• Shi L, Yang XH, Froelich CJ, Greenberg AH: Purification and use of granzyme B. In JC Reed, ed., Apoptosis, Methods in Enzymology, Vol. 322, Academic Press, 2000:125-43.
• Yang XH, Butler B, Sladek TL, Liu X, Froelich CJ, Thor AD: Reconstitution of caspase 3 sensitizes MCF-7 breast cancer cells to doxorubicin and etoposide induced apoptosis. Cancer Res 2001; 61:348-54.
• Devarajan E, Sahin AA, Chen JS, Krishnamurthy RR, Aggarwal N, Brun AM, Sapino A, Zhang F, Sharma D, Yang XH, Thor AD, Mehta K, Down-regulation of caspase 3 in breast cancer: a possible mechanism for chemoresistance. Oncogene;2002, 21:8843-51.
• Jeruss JS, Liu NX, Chung Y, Magrane G, Waldman F, Edgerton S, Yang XH, Thor AD. Characterization and chromosomal instability of novel derived cell lines from a wt-erbB-2 transgenic mouse model. Carcinogenesis. 2003, 24(4):659-64.
• Yang XH, Edgerton SM, Kosanke SD, Mason TL, Alvarez KM, Liu N, Chatterton RT, Liu B, Wang Q, Kim A, Murthy S, Thor AD. Hormonal and dietary modulation of mammary carcinogenesis in mouse mammary tumor virus-c-erbB-2 transgenic mice. Cancer Res. 2003, 63(10):2425-33.
• Liu B, Edgerton S, Yang XH, Kim A, Ordonez-Ercan D, Mason T, Alvarez K, McKimmey C, Liu N, Thor A. Low-dose dietary phytoestrogen abrogates tamoxifen-associated mammary tumor prevention. Cancer Res. 2005 65(3):879-86.
• Yang XH, Edgerton S, Thor AD. Reconstitution of caspase-3 sensitizes MCF-7 breast cancer cells to radiation therapy. Int J Oncol. 2005 Jun;26(6):1675-80.
• Kim A, Liu B, Ordonez-Ercan D, Alvarez KM, Jones LD, McKimmey C, Edgerton S, Yang XH, Thor AD. Functional interaction between mouse erbB3 and wild-type rat c-neu in transgenic mouse mammary tumor cells, Breast Cancer Research 2005, 7:R708-R718.
• Mungamuri SK, Yang XH, Thor AD, Somasundaram K. Survival signaling by Notch1: mammalian target of rapamycin (mTOR)-dependent inhibition of p53. Cancer Res. 2006 May 1;66(9):4715-24.
• Yang S, Edgerton S, Thor A and Yang XH. Csapase-3 mediated feedback activation of apical caspases in doxorubicin and TNF-alpha induced apoptosis. Apoptosis. 2006 Nov;11(11):1987-97.
• Liu B, Ordonez-Ercan D, Edgerton SM, Yang XH, and Thor AD, Down-regulation of erbB3 Abrogates c-neu/erbB2-mediated Proliferation and Tamoxifen Resistance in Breast Cancer Cell Lines. Int J Cancer. 2007 May 1;120(9):1874-82.
• Yang S, Liu J and Yang XH, Caspase status is a determinant of the differential responses in genistein treated MDA-MB-231 and MCF-7 breast cancer cells. Biochim Biophys Acta -Mol Cell Res. 2007 Jun;1773(6):903-11.
• Tophkhane C, Yang S, Bales W, Archer L, Osunkoya A, Thor AD and Yang XH, Bcl-2 overexpression sensitizes MCF-7 cells to Genistein by multiple mechanisms. Int J Oncol. 2007, Oct;31(4):867-74.
• Tophkhane CJ, Yang S, Zhao JZ and Yang XH, Cell density dependent regulation of p73. Int J Oncol. 2009. 35: 1429-1434.
• Liu B, Ercan D, Fan Z, Huang X, Edgerton S, Yang XH, Thor A. Estrogenic promotion of ErbB2 tyrosine kinase activity in mammary tumor cells requires activation of ErbB3 signaling. Mol Cancer Res, 2009:1882-92.
• Huang X, Gao L, Wang S, McManaman JL, Thor A, Yang XH, Ercan D, Esteva FJ, Liu B. Heterotrimerization of ErbB3/ErbB2/IGF-1R in trastuzumab-resistant breast cancer cells. Cancer Research, 2010 Feb 1;70(3):1204-14.
• Yang XH, Yang S, Mason TL, Liu B, Edgerton S, Thor AD. Genistein induces enhanced growth promotion in ER+/erbB-2+ breast cancer cells by ER-erbB-2 crosstalk and p27/kip1 downregulation. Carcinogenesis. 2010 Apr;31(4):695-702.
• Shi Y, Yang S, Troup S, Lu X, Callaghan S, Park DS, Xing Y, Yang XH. Resveratrol induces apoptosis in breast cancer cells by E2F1-mediated up-regulation of ASPP1. Oncol Rep. 2011 Jun;25(6):1713-9.
• Huang X, Wang S, Lee CK, Yang XH, Liu B. HDAC inhibitor SNDX-275 enhances efficacy of trastuzumab in erbB2-overexpressing breast cancer cells and exhibits potential to overcome trastuzumab resistance. Cancer Lett. 2011. 307(1):72-9.
• Balsamo, J., Leung, T.C., Ernst, H., Zanin, M.K.B., Hoffman, S., Lilien, J. 1996. Regulated binding of a PTP1b-like phosphatase to N-cadherin: control of cadherin-mediated adhesion by dephosphorylation of beta-catenin. J. Cell Biology 134:801-813.
• Balsamo, J., Arregui, C., Leung, T.C., Lilien, J. 1998. The nonreceptor protein tyrosine phosphatase PTP1B binds to the cytoplasmic domain of N-cadherin and regulates the cadherin-actin linkage. J. Cell Biology 143:523-532.
• Fekany, K., Yamanaka, Y., Leung, T.C., Sirotkin, H.I., Topczewski, J., Gates, M.A., Hibi, M., Renucci, A., Stemple, D., Radbill, A., Schier, A.F., Driever, W., Hirano, T., Talbot, W., Solnica-Krezel, L. 1999. The zebrafish bozozok locus encodes Dharma, a homeodomain protein essential for induction of gastrula organizer and dorso-anterior embryonic structures. Development 126: 1427-1438.
• Li, H., Leung, T.C., Hoffman, S., Balsamo, J., Lilien, J. 2000. Coordinate Regulation of Cadherin and Integrin Function by the Chondroitin Sulfate Proteoglycan Neurocan. J. Cell Biol. 149:1275-1288.
• Pathre, P., Arregui, C., Wampler, T., Kue, I., Leung, T.C., Lilien, J., Balsamo, J. 2001. PTP1B regulates neurite extension mediated by cell-cell and cell-matrix adhesion molecules. J. Neurosci. Res. 63:143-150.
• Doitsidou, M., Reichman-Fried, M., Stebler, J., Koprunner, M., Dorries, J., Meyer, D., Esguerra, C.V., Leung, T., Raz, E. 2002. Guidance of primordial germ cell migration by the chemokine SDF-1. Cell 111:647-659.
• Leung T, Bischof J, Söll I, Niessing D, Zhang D, Ma J, Jackle H, Driever W. 2003. bozozok directly represses bmp2b transcription and mediates the earliest dorsoventral asymmetry of bmp2b expression in Zebrafish. Development 130:3639-3649.
• Leung, T., Söll, I., Arnold, S., Wolf, K., Driever, W. 2003. Direct binding of Lef1 to sites in the boz promoter may mediate pre-midblastula-transition activation of boz expression. Developmental Dynamics (zebrafish special issue) 228:424–432.
• Leung, T., Chen, H., Stauffer, A.M., Giger, K.E., Sinha, S., Horstick, E.J., Humbert, J.E., Hansen, C.A. and Robishaw, J.D. 2006. Zebrafish G protein g2 is required for VEGF signalling during angiogenesis. Blood 108:160-166.
• Chen, H., Leung, T., Giger, K.E., Stauffer, A.M., Humbert, J.E., Sinha, S., Horstick, E.J., Hansen, C.A., Robishaw, J.D. 2007. Expression of the G protein gamma T1 subunit during zebrafish development. Gene Expression Pattern 7:574-583.
• Leung, T., Humbert, J.E., Stauffer, A.M., Giger, K.E., Chen, H., Tsai, H.-J., Wang, C., Mirshahi, T., Robishaw, J.D. 2008. The orphan G protein coupled receptor 161 is required for left-right patterning. Developmental Biology 323:31-40.